Acute kidney injury is still associated with high morbidity and mortality. Reichardt et al. investigated DNA-binding protein-A (Ybx3) in acute kidney injury induced by ischemia-reperfusion injury and found that mice lacking Ybx3 have altered mitochondrial function and increased antioxidant activity, making them more resistant to ischemia-reperfusion injury–acute kidney injury. The study highlights a new role of the multifaceted protein DNA-binding protein-A, which could be potentially therapeutically exploited.

中文翻译：

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DNA 结合蛋白-A：肾小管上皮细胞中的多工具


急性肾损伤仍然与高发病率和死亡率相关。Reichardt 等 人研究了缺血再灌注损伤诱导的急性肾损伤中的 DNA 结合蛋白 A （Ybx3），发现缺乏 Ybx3 的小鼠线粒体功能发生了变化，抗氧化活性增加，使它们对缺血再灌注损伤-急性肾损伤更具抵抗力。该研究强调了多方面蛋白质 DNA 结合蛋白 A 的新作用，可能被潜在地用于治疗。