Nuclear and radiological accidents can occur due to poor management, in transportation, radiation therapy and nuclear wards in hospitals, leading to extreme radiation exposure and serious consequences for human health. Additionally, in many of previous radiological accidents, skin damage was observed in patients and survivors due to the high radiation exposure. However, as part of a medical countermeasures in a nuclear/radiological emergency, it is critical to plan for the treatment of radiation-induced skin damage. Hence, the new, non-invasive technology of photodynamic therapy (PDT) is projected to be more effectively used for treating skin damage caused by high-dose radiation. PDT plays an important role in treating, repairing skin damage and promoting wound healing as evidenced by research. This review, highlighted and recommended potential impacts of PDT to repair and decrease radiation-induced skin tissue damage. Moreover, we have suggested some photosensitizer (PS) agent as radio-mitigator drugs to decrease radiobiological effects.

中文翻译：

---

光动力疗法在减轻核或放射紧急情况下皮肤损伤方面的预期作用：综述


由于运输、放射治疗、医院核病房等管理不善，可能会发生核放射事故，导致极度辐射照射，对人体健康造成严重后果。此外，在之前的许多放射事故中，由于高辐射暴露，患者和幸存者都出现了皮肤损伤。然而，作为核/辐射紧急情况下医疗对策的一部分，制定辐射引起的皮肤损伤的治疗计划至关重要。因此，新型非侵入性光动力疗法（PDT）技术预计将更有效地用于治疗高剂量辐射引起的皮肤损伤。研究证明，PDT 在治疗、修复皮肤损伤和促进伤口愈合方面发挥着重要作用。这篇综述强调并推荐了 PDT 对修复和减少辐射引起的皮肤组织损伤的潜在影响。此外，我们建议使用一些光敏剂（PS）作为放射缓解药物来减少放射生物学效应。