This study aimed to explore whether there is an association between environmental exposure to POPs and kidney tumor induction, and whether blood POP concentrations reflect kidney tissue concentrations. POP derivatives were determined in blood, tumor tissue, tumor surrounding tissue, and perirenal fat tissue samples taken from patients who underwent surgery for renal tumors. A voluntary control group was recruited for blood and urine samples as well. Urinary excretions of -dityrosine, chlorotyrosine, nitrotyrosine, and 8-OHdG were measured in the same patients. The possible role of genetic polymorphisms in CYP1A1, GST isozymes P, M, and T, and hOGG1 genes on the predisposition to renal cancer was investigated. Some POPs have been found to be associated with kidney cancer, as evidenced by their significantly high ORs. 8-OHdG levels were significantly higher compared to the control group. The GSTT1 null polymorphism can be a risk factor for malignant but not for benign kidney tumors.

中文翻译：

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组织持久性有机污染物及基因多态性在良恶性肾肿瘤患者中的作用


本研究旨在探讨 POPs 环境暴露与肾肿瘤诱发之间是否存在关联，以及血液 POP 浓度是否反映肾组织浓度。在接受肾肿瘤手术的患者的血液、肿瘤组织、肿瘤周围组织和肾周脂肪组织样本中测定了 POP 衍生物。还招募了一个自愿对照组来采集血液和尿液样本。测量了同一患者的 β-二酪氨酸、氯酪氨酸、硝基酪氨酸和 8-OHdG 的尿排泄量。研究了 CYP1A1、GST 同工酶 P、M 和 T 以及 hOGG1 基因的遗传多态性对肾癌易感性的可能作用。一些持久性有机污染物已被发现与肾癌相关，其 OR 显着较高就证明了这一点。与对照组相比，8-OHdG 水平显着升高。 GSTT1 无效多态性可能是恶性肾肿瘤的危险因素，但不是良性肾肿瘤的危险因素。