Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60-69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study.,Environmental Health Perspectives

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Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60-69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study.
Environmental Health Perspectives ( IF 10.1 ) Pub Date : 2024-07-19 , DOI: 10.1289/ehp13865
Peijie Sun _{1,

2} , Xiaojie Guo _{1,

3} , Enmin Ding _{1,

4} , Chenfeng Li _{1,

5} , Huimin Ren _{1,

2} , Yibo Xu _{1,

6} , Jiankun Qian _{1,

2} , Fuchang Deng ₁ , Wanying Shi ₇ , Haoran Dong ₁ , Elizabeth Z Lin ₈ , Pengfei Guo ₈ , Jianlong Fang ₁ , Qian Zhang ₉ , Wenhua Zhao ₉ , Shilu Tong _{1,

10} , Xiaobo Lu ₂ , Krystal J Godri Pollitt ₈ , Xiaoming Shi _{1,

11} , Song Tang _{1,

12}

Affiliation

China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.
Department of Toxicology, School of Public Health, China Medical University, Shenyang, China.
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, and Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA.
Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing, China.
School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia.
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.
Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.

BACKGROUND Evidence suggested that abiotic airborne exposures may be associated with changes in body composition. However, more evidence is needed to identify key pollutants linked to adverse health effects and their underlying biomolecular mechanisms, particularly in sensitive older adults. OBJECTIVES Our research aimed to systematically assess the relationship between abiotic airborne exposures and changes in body composition among healthy older adults, as well as the potential mediating mechanisms through the serum lipidome. METHODS From September 2018 to January 2019, we conducted a monthly survey among 76 healthy adults (60-69 years old) in the China Biomarkers of Air Pollutant Exposure (BAPE) study, measuring their personal exposures to 632 abiotic airborne pollutions using MicroPEM and the Fresh Air wristband, 18 body composition indicators from the InBody 770 device, and lipidomics from venous blood samples. We used an exposome-wide association study (ExWAS) and deletion/substitution/addition (DSA) model to unravel complex associations between exposure to contaminant mixtures and body composition, a Bayesian kernel machine regression (BKMR) model to assess the overall effect of key exposures on body composition, and mediation analysis to identify lipid intermediators. RESULTS The ExWAS and DSA model identified that 2,4,5-T methyl ester (2,4,5-TME), 9,10-Anthracenedione (ATQ), 4b,8-dimethyl-2-isopropylphenanthrene, and 4b,5,6,7,8,8a,9,10-octahydro-(DMIP) were associated with increased body fat mass (BFM), fat mass indicators (FMI), percent body fat (PBF), and visceral fat area (VFA) in healthy older adults [Bonferroni-Hochberg false discovery rate (FDRBH)<0.05]. The BKMR model demonstrated a positive correlation between contaminants (anthracene, ATQ, copaene, di-epi-α-cedrene, and DMIP) with VFA. Mediation analysis revealed that phosphatidylcholine [PC, PC(16:1e/18:1), PC(16:2e/18:0)] and sphingolipid [SM, SM(d18:2/24:1)] mediated a significant portion, ranging from 12.27% to 26.03% (p-value <0.05), of the observed increase in VFA. DISCUSSION Based on the evidence from multiple model results, ATQ and DMIP were statistically significantly associated with the increased VFA levels of healthy older adults, potentially regulated through lipid intermediators. These findings may have important implications for identifying potentially harmful environmental chemicals and developing targeted strategies for the control and prevention of chronic diseases in the future, particularly as the global population is rapidly aging. https://doi.org/10.1289/EHP13865.

更新日期：2024-07-19

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