OBJECTIVE To examine the safety and efficacy of a brief cognitive dual-task (using eye movements) add-on module to treatment as usual (TAU) in reducing the severity and frequency of intrusive suicidal mental images and suicidal ideation. METHOD We conducted a single-blind, parallel multicenter randomized trial (No. NTR7563) among adult psychiatric outpatients (N = 91; Mage = 34.4, SD = 13.54; 68% female) with elevated depressive symptoms and experiencing distressing suicidal intrusions in the Netherlands. Primary outcome was the severity (Suicidal Intrusions Attributes Scale) and frequency (Clinical Interview for Suicidal Intrusions) of suicidal mental imagery intrusions at 1-week posttreatment and 3-month follow-up. Primary analysis was intention-to-treat. RESULTS Between November 27, 2018 and September 13, 2021, 91 patients were included and randomly assigned to intervention group (Cognitive Dual Task Add-on + TAU) (n = 46) or TAU-only (n = 45). Cognitive Dual Task Add-on + TAU had greater reductions in severity (mean difference, -15.50, 95% CI [23.81, -7.19]; p < .001, d = 0.60), and frequency (geometric mean difference, 0.47, 95% CI [0.29, 0.79]; p = .004) of suicidal intrusions over time than TAU-alone. Cognitive Dual Task Add-on + TAU patients also showed lower suicidal ideation over time (p = .008, d = 0.42). There were no significant group differences in reductions in depressive symptoms, rumination, or hopelessness. Four serious adverse events occurred (three Cognitive Dual Task Add-on + TAU; one TAU-only); all unlikely attributable to intervention/trial. CONCLUSIONS Findings provide support for the effectiveness of adding a cognitive dual-task module to the treatment of psychiatric outpatients with elevated depressive symptoms in reducing suicidal intrusions and ideation and can be executed safely. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

中文翻译：

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通过双任务附加模块减少抑郁症状患者的侵入性自杀心理图像：多中心随机临床试验的结果。


目的 检验常规治疗 (TAU) 的简短认知双任务（使用眼动）附加模块在降低侵入性自杀心理意象和自杀意念的严重程度和频率方面的安全性和有效性。方法 我们在荷兰的成年精神科门诊患者（N = 91；Mage = 34.4，SD = 13.54；68% 女性）中进行了一项单盲、平行多中心随机试验（No. NTR7563），这些患者患有抑郁症状并经历过令人痛苦的自杀行为。主要结局是治疗后 1 周和 3 个月随访时自杀心理意象侵入的严重程度（自杀侵入属性量表）和频率（自杀侵入临床访谈）。主要分析是意向治疗。结果 2018年11月27日至2021年9月13日期间，纳入了91名患者，并随机分配到干预组（认知双任务附加+ TAU）（n = 46）或仅TAU（n = 45）。认知双重任务附加 + TAU 在严重程度（平均差，-15.50，95% CI [23.81，-7.19]；p < .001，d = 0.60）和频率（几何平均差，0.47，随着时间的推移，与单独使用 TAU 相比，自杀入侵的置信区间为 95% CI [0.29, 0.79]；p = .004)。随着时间的推移，认知双重任务附加 + TAU 患者的自杀意念也较低（p = .008，d = 0.42）。抑郁症状、沉思或绝望的减少没有显着的组间差异。发生了 4 起严重不良事件（3 起认知双任务附加 + TAU；1 起仅 TAU）；所有这些都不太可能归因于干预/试验。 结论 研究结果支持在抑郁症状加重的精神病门诊患者的治疗中添加认知双任务模块可以有效减少自杀侵入和意念，并且可以安全地执行。 （PsycInfo 数据库记录 (c) 2024 APA，保留所有权利）。