OBJECTIVE To examine the safety and efficacy of a brief cognitive dual-task (using eye movements) add-on module to treatment as usual (TAU) in reducing the severity and frequency of intrusive suicidal mental images and suicidal ideation. METHOD We conducted a single-blind, parallel multicenter randomized trial (No. NTR7563) among adult psychiatric outpatients (N = 91; Mage = 34.4, SD = 13.54; 68% female) with elevated depressive symptoms and experiencing distressing suicidal intrusions in the Netherlands. Primary outcome was the severity (Suicidal Intrusions Attributes Scale) and frequency (Clinical Interview for Suicidal Intrusions) of suicidal mental imagery intrusions at 1-week posttreatment and 3-month follow-up. Primary analysis was intention-to-treat. RESULTS Between November 27, 2018 and September 13, 2021, 91 patients were included and randomly assigned to intervention group (Cognitive Dual Task Add-on + TAU) (n = 46) or TAU-only (n = 45). Cognitive Dual Task Add-on + TAU had greater reductions in severity (mean difference, -15.50, 95% CI [23.81, -7.19]; p < .001, d = 0.60), and frequency (geometric mean difference, 0.47, 95% CI [0.29, 0.79]; p = .004) of suicidal intrusions over time than TAU-alone. Cognitive Dual Task Add-on + TAU patients also showed lower suicidal ideation over time (p = .008, d = 0.42). There were no significant group differences in reductions in depressive symptoms, rumination, or hopelessness. Four serious adverse events occurred (three Cognitive Dual Task Add-on + TAU; one TAU-only); all unlikely attributable to intervention/trial. CONCLUSIONS Findings provide support for the effectiveness of adding a cognitive dual-task module to the treatment of psychiatric outpatients with elevated depressive symptoms in reducing suicidal intrusions and ideation and can be executed safely. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

中文翻译：

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通过双重任务附加模块减少抑郁症状患者的侵入性自杀心理图像：一项多中心随机临床试验的结果。


目的 检查常规治疗 （TAU） 的简短认知双重任务 （使用眼球运动） 附加模块在降低侵入性自杀心理图像和自杀意念的严重程度和频率方面的安全性和有效性。方法 我们进行了一项单盲、平行、多中心随机试验 （No.NTR7563） 在成人精神病门诊患者中 （N = 91;法师 = 34.4，SD = 13.54;68% 为女性），抑郁症状加重，并在荷兰经历令人痛苦的自杀侵入。主要结局是治疗后 1 周和 3 个月随访时自杀心理意象侵入的严重程度 （自杀侵入属性量表） 和频率 （自杀侵入临床访谈）。主要分析是意向性治疗。结果 2018 年 11 月 27 日至 2021 年 9 月 13 日期间，纳入 91 例患者并随机分配到干预组 （认知双重任务附加组件 + TAU） （n = 46） 或仅 TAU 组 （n = 45）。与单独使用 TAU 相比，认知双重任务附加 + TAU 在自杀侵入的严重程度（均数差，-15.50,95% CI [23.81，-7.19];p < .001，d = 0.60）和频率（几何均数差，0.47,95% CI [0.29,0.79];p = .004）方面降低幅度更大。随着时间的推移，认知双重任务附加组件 + TAU 患者的自杀意念也表现出较低的 （p = .008，d = 0.42）。在抑郁症状、反刍或绝望的减轻方面没有显著的组间差异。发生了 4 例严重不良事件（3 例认知双任务附加组件 + TAU;1 例仅 TAU）;都不太可能归因于干预/试验。 结论 研究结果为在抑郁症状加重的精神病门诊患者治疗中增加认知双重任务模块在减少自杀侵入和意念方面的有效性提供了支持，并且可以安全地执行。（PsycInfo 数据库记录 （c） 2024 APA，保留所有权利）。