While notable improvements in survival, the incidence of hemocompatibility-related adverse events, hospitalizations, and cost have been demonstrated with the only commercially available durable left ventricular assist device, a category of pump malfunctions characterized by outflow graft obstruction has been noted with broader use and clinical follow-up of recipients of this technology. Of particular concern is the accumulation of acellular biodebris between the outflow graft and bend relief covering the outflow graft at its origin with the pump (which we term extrinsic outflow graft obstruction at the bend relief). This process tends to be insidious, occurs late in the postoperative course, can be challenging to diagnose, and can result in significant morbidity and mortality. Herein, we provide a review of this complication and outline diagnostic, treatment, and preventive strategies.

中文翻译：

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HeartMate 3 LVAD 的外源性流出移植物阻塞：最先进的综述。


虽然唯一市售的耐用左心室辅助装置在生存率、血相性相关不良事件的发生率、住院治疗和成本方面已得到显着改善，但随着该技术接受者的广泛使用和临床随访，已经注意到一类以流出移植物阻塞为特征的泵功能障碍。特别令人担忧的是流出移植物和弯曲浮雕之间的脱细胞生物碎片的积累，用泵在其起点覆盖流出嫁接物（我们称之为弯曲浮雕处的外源性流出移植物阻塞）。这个过程往往是隐匿的，发生在术后病程的后期，可能难以诊断，并可能导致严重的并发症发生率和死亡率。在本文中，我们提供了对这种并发症的回顾，并概述了诊断、治疗和预防策略。