INTRODUCTION Tobacco smoking is a major risk factor for various diseases worldwide, including pancreatic exocrine diseases such as pancreatitis and pancreatic cancer (PC). Currently, few studies have examined the impact of smoking cessation on the likelihood of common pancreatic exocrine diseases. This study sought to determine whether smoking cessation would reduce pancreatitis and PC morbidity. METHODS This cohort study used data from the UK Biobank (UKB) to examine the association between smoking status and the likelihood of pancreatitis and PC among 492855 participants. The subjects were divided into never smokers, ex-smokers, and current smokers. Using a multivariate-adjusted binary logistic regression model, we analyzed the relationship between different smoking conditions and the likelihood of pancreatitis and PC. Further, we studied the impact of smoking cessation on pancreatitis and PC compared with current smoking. RESULTS After adjusting for potential confounders, current smokers had higher odds for acute pancreatitis (AP) (AOR=1.38; 95% CI: 1.18-1.61), chronic pancreatitis (CP) (AOR=3.29; 95% CI: 2.35-4.62) and PC (AOR=1.72; 95% CI: 1.42-2.09). People who quit smoking had comparable odds for the diseases as those who never smoked. Compared with current smokers, ex-smokers had reduced odds for AP (AOR=0.76; 95% CI: 0.64-0.89), CP (AOR=0.31; 95% CI: 0.21-0.46), and PC (AOR=0.62; 95% CI: 0.50-0.76). Subgroup analysis revealed reduced odds for these pancreatic diseases in males and females. CONCLUSIONS Smokers have an increased odds for pancreatitis and pancreatic cancer. Moreover, smoking cessation can significantly reduce the odds for acute pancreatitis, chronic pancreatitis and pancreatic cancer.

中文翻译：

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戒烟对胰腺炎和胰腺癌可能性的影响。


简介 吸烟是全世界多种疾病的主要危险因素，包括胰腺炎和胰腺癌（PC）等胰腺外分泌疾病。目前，很少有研究探讨戒烟对常见胰腺外分泌疾病可能性的影响。本研究旨在确定戒烟是否会降低胰腺炎和 PC 的发病率。方法 这项队列研究使用英国生物银行 (UKB) 的数据来检查 492855 名参与者的吸烟状况与胰腺炎和 PC 的可能性之间的关联。受试者分为从不吸烟者、戒烟者和当前吸烟者。使用多变量调整二元逻辑回归模型，我们分析了不同吸烟条件与胰腺炎和 PC 可能性之间的关系。此外，我们还研究了与当前吸烟相比，戒烟对胰腺炎和 PC 的影响。结果调整潜在混杂因素后，当前吸烟者患急性胰腺炎（AP）（AOR=1.38；95% CI：1.18-1.61）、慢性胰腺炎（CP）（AOR=3.29；95% CI：2.35-4.62）的几率较高和 PC（AOR=1.72；95% CI：1.42-2.09）。戒烟的人患这些疾病的几率与从不吸烟的人相当。与当前吸烟者相比，戒烟者发生 AP（AOR=0.76；95% CI：0.64-0.89）、CP（AOR=0.31；95% CI：0.21-0.46）和 PC（AOR=0.62；95）的几率降低。 % CI：0.50-0.76）。亚组分析显示男性和女性患这些胰腺疾病的几率降低。结论 吸烟者患胰腺炎和胰腺癌的几率增加。而且，戒烟可以显着降低急性胰腺炎、慢性胰腺炎和胰腺癌的发病几率。