Pharmaceutical active compounds (PhACs) are detected pollutants in aquatic environments worldwide at concentrations ranging from ng L to µg L. Currently, PhAC monitoring is poorly realized in Mexico. This study proposes a priority list of PhACs in Mexican aquatic environments, considering their occurrence and environmental and human health risks. Ecological risks were assessed as Risk Quotients (RQ) values using the PhAC concentrations detected in surface water, obtaining high risks (RQ > 1) against aquatic organisms, especially of naproxen, ibuprofen, diclofenac, acetaminophen, 17β-estradiol carbamazepine, ketoprofen caffeine. In contrast, potential human health risks (RQ) were assessed on the Mexican population using the concentrations quantified in groundwater, demonstrating potential risks (RQ > 0.2) on the population, particularly of DCF and CBZ. Thus, a priority list of PhACs can be used as a reference for environmental monitoring in Mexican water supplies as well as PhACs monitoring in countries of the Caribbean region and Central America.

中文翻译：

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考虑到墨西哥水生环境中药物活性化合物的出现、环境和人类健康风险，优先列出这些化合物


药物活性化合物 (PhAC) 是全球水生环境中检测到的污染物，浓度范围为 ng·L 至 µg·L。目前，墨西哥的 PhAC 监测实施情况较差。考虑到 PhAC 的出现以及环境和人类健康风险，本研究提出了墨西哥水生环境中 PhAC 的优先列表。使用地表水中检测到的 PhAC 浓度将生态风险评估为风险商 (RQ) 值，获得针对水生生物的高风险 (RQ > 1)，特别是萘普生、布洛芬、双氯芬酸、对乙酰氨基酚、17β-雌二醇卡马西平、酮洛芬咖啡因。相比之下，使用地下水中量化的浓度对墨西哥人口进行了潜在人类健康风险 (RQ) 评估，显示了对人口的潜在风险 (RQ > 0.2)，特别是 DCF 和 CBZ。因此，PhAC 优先列表可用作墨西哥供水环境监测以及加勒比地区和中美洲国家 PhAC 监测的参考。