Oral microbiome, periodontal disease and systemic bone-related diseases in the era of homeostatic medicine,Journal of Advanced Research

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Oral microbiome, periodontal disease and systemic bone-related diseases in the era of homeostatic medicine
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2024-08-17 , DOI: 10.1016/j.jare.2024.08.019
Weiqi Hu ₁ , Shuoling Chen ₁ , Xianghui Zou ₁ , Yan Chen ₂ , Jiayu Luo ₁ , Peiliang Zhong ₁ , Dandan Ma ₁

Affiliation

Background

Homeostasis is a state of self-regulation and dynamic equilibrium, maintaining the good physiological functions of each system in living organisms. In the oral cavity, the interaction between the host and the oral microbiome forms oral microbial homeostasis. Physiological bone remodeling and renewal can occur under the maintenance of oral microbial homeostasis. The imbalance of bone homeostasis is a key mechanism leading to the occurrence of systemic bone-related diseases. Considering the importance of oral microbial homeostasis in the maintenance of bone homeostasis, it still lacks a complete understanding of the relationship between oral microbiome, periodontal disease and systemic bone-related diseases.

Aim of review

This review focuses on the homeostatic changes, pathogenic routes and potential mechanisms in the oral microbiome in periodontal disease and systemic bone-related diseases such as rheumatoid arthritis, osteoarthritis, osteoporosis and osteomyelitis. Additionally, this review discusses oral microbiome-based diagnostic approaches and explores probiotics, mesenchymal stem cells, and oral microbiome transplantation as promising treatment strategies.

Key scientific concepts of review

This review highlights the association between oral microbial homeostasis imbalance and systemic bone-related diseases, and highlights the possibility of remodeling oral microbial homeostasis for the prevention and treatment of systemic bone-related diseases.

中文翻译：

稳态医学时代的口腔微生物组、牙周病和全身性骨相关疾病

背景

体内平衡是一种自我调节和动态平衡的状态，维持生物体中各个系统的良好生理功能。在口腔中，宿主与口腔微生物组之间的相互作用形成口腔微生物稳态。生理性骨重塑和更新可以在口腔微生物稳态的维持下发生。骨稳态失衡是导致系统性骨相关疾病发生的关键机制。考虑到口腔微生物稳态在维持骨稳态中的重要性，对口腔微生物组、牙周病和全身性骨相关疾病之间的关系仍缺乏完整的了解。