Lactate synthesis via lactate dehydrogenase A (LDHA), traditionally considered to be a 'disallowed' function in pancreatic β cells, is redefined by Cuozzo et al. who find that lactate produced by β cells regulates fasting insulin secretion via LDHB. The metabolic sources, fates, and relevance of β cell lactate are further examined.

中文翻译：

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重新考虑胰腺 β 细胞中乳酸的不允许。


Cuozzo 等人重新定义了通过乳酸脱氢酶 A (LDHA) 合成乳酸，传统上被认为是胰腺 β 细胞中“不允许的”功能。他们发现 β 细胞产生的乳酸通过 LDHB 调节空腹胰岛素分泌。进一步研究了β细胞乳酸的代谢来源、命运和相关性。