The interaction of reactive oxygen species with cell membrane lipids is usually considered in the context of lipid peroxidation in the nonpolar component of the membrane. In this work, for the first time, data were obtained indicating that damage to human cell membranes can occur in the polar part of lysophospholipids at the interface with the aqueous environment due to free radical fragmentation (FRF) processes. FRF products, namely 1-hexadecanoyloxyacetone (PAc) and 1-octadecanoyloxyacetone (SAc), were identified in human serum, and a GC-MS method was developed to quantify PAc and SAc.

中文翻译：

---

溶血磷脂极性部分的自由基断裂和氧化：健康供体和急性手术病理患者血清的研究结果


活性氧与细胞膜脂质的相互作用通常在膜非极性成分中脂质过氧化的背景下考虑。在这项工作中，首次获得的数据表明，由于自由基断裂（FRF）过程，在与水环境界面的溶血磷脂的极性部分可能会发生对人体细胞膜的损害。在人血清中鉴定出 FRF 产物，即 1-十六酰氧基丙酮 (PAc) 和 1-十八酰氧基丙酮 (SAc)，并开发了 GC-MS 方法来定量 PAc 和 SAc。