In a recent article, demonstrate that GPR75 knock-out in mice results in lower body fat and reduced hepatic lipid accumulation, with an increase in physical activity and energy expenditure. Loss-of-function (LoF) GPR75 variants in the UK Biobank (UKBB) are associated with reduced liver steatosis, suggesting potential therapeutic implications in metabolic dysfunction-associated steatotic liver disease (MASLD).

中文翻译：

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拯救肥胖和脂肪肝的孤儿？


在最近的一篇文章中，证明小鼠 GPR75 敲除会导致身体脂肪降低并减少肝脏脂质积累，同时体力活动和能量消耗增加。英国生物库 (UKBB) 中的功能丧失 (LoF) GPR75 变异体与肝脏脂肪变性减少相关，这表明对代谢功能障碍相关的脂肪肝病 (MASLD) 具有潜在的治疗意义。