Obesity is often associated with adipose tissue (AT) inflammation and immune cell infiltration. Writing recently in Cell Reports, Liao et al. investigated the mechanisms of T cell infiltration of AT using single cell (sc)RNA-sequencing (RNA-seq), transplantation studies, in vitro co-cultures, and knock-out mice. They highlighted the crucial role of C-C motif chemokine ligand 5 (CCL5)-secreting adipose stem cells (ASCs), offering insights for potential therapies.

中文翻译：

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脂肪干细胞驱动肥胖症中的 T 细胞浸润


肥胖通常与脂肪组织 （AT） 炎症和免疫细胞浸润有关。Liao 等人最近在《细胞报告》上撰文，使用单细胞 （sc）RNA 测序 （RNA-seq）、移植研究、体外共培养和基因敲除小鼠研究了 AT 的 T 细胞浸润机制。他们强调了 C-C 基序趋化因子配体 5 （CCL5） 分泌脂肪干细胞 （ASC） 的关键作用，为潜在疗法提供了见解。