Despite standard treatment efforts, patients with glioblastoma (GBM), an aggressive form of brain cancer, inevitably succumb to recurrent disease. Integrative genomic analyses reveal that tumor cells hijack normal neurodevelopmental pathways to promote GBM growth and invasion. To target this pathway, we engineer a CAR T cell therapy that blocks the growth of GBM and other invasive brain cancers.

中文翻译：

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使用 ROBO1 CAR T 细胞发现和靶向浸润性脑癌中的脆弱性


尽管采取了标准的治疗措施，但胶质母细胞瘤 （GBM）（一种侵袭性脑癌）患者不可避免地会死于复发性疾病。整合基因组分析显示，肿瘤细胞劫持正常的神经发育途径以促进 GBM 生长和侵袭。为了靶向这条通路，我们设计了一种 CAR T 细胞疗法，可阻断 GBM 和其他浸润性脑癌的生长。