<br>AP-2 转录因子家族——在胃肠道疾病中的调节作用仍然被低估,International Journal of Molecular Sciences

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AP-2 转录因子家族——在胃肠道疾病中的调节作用仍然被低估
International Journal of Molecular Sciences ( IF 4.9 ) Pub Date : 2024-08-23 , DOI: 10.3390/ijms25179138
Yi-Jin Yu _{1,

2} , Damian Kołat _{3,

4} , Żaneta Kałuzińska-Kołat _{3,

4} , Zhu Liang _{5,

6} , Bo-Qiang Peng _{1,

2} , Yun-Feng Zhu _{1,

2} , Kai Liu _{1,

2} , Jia-Xin Mei _{1,

2} , Gang Yu _{1,

2} , Wei-Han Zhang _{1,

2} , Xiao-Long Chen _{1,

2} , Kun Yang _{1,

2} , Jian-Kun Hu _{1,

2} , Lin-Yong Zhao _{1,

2}

Affiliation

激活增强子结合蛋白 2 (AP-2) 是一个转录因子 (TF) 家族，在调节胚胎和致癌发育中发挥着至关重要的作用。除了剪接亚型外，在人类中还鉴定了由 TFAP2A/B/C/D/E 基因编码的五个主要家族成员，即 AP-2α/β/γ/δ/ε。一般来说，前三个 TF 比 AP-2δ 或 AP-2ε 研究得更彻底。目前，在胃肠病学研究背景下，关注 AP-2 家族的文献相对有限，并且缺乏对现有知识的全面概述和对进一步研究方向的建议。在此，我们收集了 AP-2 TF 的现有胃肠病学数据，讨论了每个家庭成员的最新医学应用，并提出了潜在的未来方向。 AP-2 在胃肠道肿瘤中的研究主要集中在两个最有描述的家族成员：AP-2α 和 AP-2γ。令人惊讶的是，过去十年的研究强调了 AP-2ε 在胃癌 (GC) 和结直肠癌 (CRC) 耐药性中的重要性。虽然有关胃肠道疾病的许多问题有待阐明，但现有数据无疑为抗癌靶向治疗和克服化疗耐药性开辟了途径。除了胃肠道癌症外，AP-2 家族成员（主要是 AP-2β，少量是 AP-2γ）还与其他健康问题相关，例如肥胖、2 型糖尿病、肝功能障碍和假性梗阻。另一方面，AP-2δ 在胃肠道疾病中的研究很少，需要进一步研究来阐明其作用。总之，尽管胃肠病学研究中对 AP-2 的关注有限，但这些转录因子的关键功能已经开始出现，值得未来进一步探索。

"点击查看英文标题和摘要"

The AP-2 Family of Transcription Factors—Still Undervalued Regulators in Gastroenterological Disorders

Activating enhancer-binding protein 2 (AP-2) is a family of transcription factors (TFs) that play crucial roles in regulating embryonic and oncogenic development. In addition to splice isoforms, five major family members encoded by the TFAP2A/B/C/D/E genes have been identified in humans, i.e., AP-2α/β/γ/δ/ε. In general, the first three TFs have been studied more thoroughly than AP-2δ or AP-2ε. Currently, there is a relatively limited body of literature focusing on the AP-2 family in the context of gastroenterological research, and a comprehensive overview of the existing knowledge and recommendations for further research directions is lacking. Herein, we have collected available gastroenterological data on AP-2 TFs, discussed the latest medical applications of each family member, and proposed potential future directions. Research on AP-2 in gastrointestinal tumors has predominantly been focused on the two best-described family members, AP-2α and AP-2γ. Surprisingly, research in the past decade has highlighted the importance of AP-2ε in the drug resistance of gastric cancer (GC) and colorectal cancer (CRC). While numerous questions about gastroenterological disorders await elucidation, the available data undoubtedly open avenues for anti-cancer targeted therapy and overcoming chemotherapy resistance. In addition to gastrointestinal cancers, AP-2 family members (primarily AP-2β and marginally AP-2γ) have been associated with other health issues such as obesity, type 2 diabetes, liver dysfunction, and pseudo-obstruction. On the other hand, AP-2δ has been poorly investigated in gastroenterological disorders, necessitating further research to delineate its role. In conclusion, despite the limited attention given to AP-2 in gastroenterology research, pivotal functions of these transcription factors have started to emerge and warrant further exploration in the future.

更新日期：2024-08-23

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