Objectives The objectives of this study are to examine the association of physical activity in parents with physical activity in their adult offspring and explore if the offspring’s genetic liability (ie, polygenic risk score) to physical activity influences this association. Methods The Trøndelag Health Study cohort is a population-based longitudinal study with data collected in 1984–1986, 1995–1997, 2006–2008 and 2017–2019. We calculated the odds ratio for being physically active and mean difference in physical activity levels according to parental physical activity (device-measured and self-reported) and own polygenic risk score. Results Compared with offspring with mothers in the lowest third of metabolic equivalent of task (MET)-min/day accumulated by vigorous physical activities, offspring with mothers in the upper third had an OR of 1.93 (95% CI 1.65 to 2.27) for accumulating ≥900 MET-min/week of vigorous physical activity. The OR for the corresponding father–offspring association was 1.78 (95% CI 1.48 to 2.14). Compared with offspring of parents not accumulating ≥900 MET-min/week, we found an OR of 1.89 (95% CI 1.45 to 2.44) for offspring to meet the same threshold if both parents accumulated ≥900 MET-min/week. Offspring with higher polygenic risk score to bephysically active and having physically active parents did more weekly physical activity, but we found no strong evidence of multiplicative synergistic effects between these two factors (all p values ≥0.01). Conclusion Both parental physical activity and offspring’s polygenic risk score were positively associated with physical activity levels in the adult offspring, but there was no evidence of effect modification between these factors. A family-based approach to promote physical activity may be effective from a public health perspective. Data are available upon reasonable request. The data that support the findings of this study are available from HUNT Research Centre () but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are however available from the coauthor “Paul Jarle Mork” (email ID: paul.mork@ntnu.no) upon reasonable request and with permission from HUNT Research Centre ().

中文翻译：

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代际和遗传对身体活动的影响：来自挪威 HUNT 研究的家庭数据


目的 本研究的目的是检查父母身体活动与成年后代身体活动的关联，并探讨后代对身体活动的遗传易感性（即多基因风险评分）是否会影响这种关联。方法 Trøndelag 健康研究队列是一项基于人群的纵向研究，收集了 1984-1986 年、1995-1997 年、2006-2008 年和 2017-2019 年的数据。我们根据父母的身体活动 （设备测量和自我报告） 和自己的多基因风险评分计算了身体活动的比值比和身体活动水平的平均差异。结果 与母亲通过剧烈体育活动积累的任务代谢当量 （MET） 最低三分之一的后代相比，母亲处于上三分之一的后代积累 ≥900 MET-min/周的剧烈体力活动。相应父子关联的 OR 为 1.78 （95% CI 1.48 至 2.14）。与父母未积累 ≥900 MET-min/周的后代相比，我们发现如果父母双方都积累 ≥900 MET-min/周，则后代达到相同阈值的 OR 为 1.89（95% CI 1.45 至 2.44）。具有较高多基因风险评分的后代对身体活动和身体活跃的父母每周进行更多的身体活动，但我们没有发现这两个因素之间存在乘法协同效应的有力证据 （均 p 值 ≥0.01）。结论 父母体力活动和子代多基因风险评分均与成年后代的体力活动水平呈正相关，但尚无证据表明这些因素之间的影响发生改变。 从公共卫生的角度来看，以家庭为基础的促进身体活动的方法可能是有效的。数据可根据合理要求提供。支持本研究结果的数据可从 HUNT 研究中心 （） 获得，但这些数据的可用性受到限制，这些数据是在当前研究的许可下使用的，因此不公开可用。然而，经合理要求并得到 HUNT 研究中心 （） 的许可，可从合著者“Paul Jarle Mork”（电子邮件 ID：paul.mork@ntnu.no）处获得数据。