One-carbon metabolism (1CM), comprising folate metabolism and methionine metabolism, serves as an important mechanism for cellular energy provision and the production of vital signaling molecules, including single-carbon moieties. Its regulation is instrumental in sustaining the proliferation of cancer cells and facilitating metastasis; in addition, recent research has shed light on its impact on the efficacy of T cell-mediated immunotherapy. In this review, we consolidate current insights into how 1CM affects T cell activation, differentiation, and functionality. Furthermore, we delve into the strategies for modulating 1CM in both T cells and tumor cells to enhance the efficacy of adoptively transferred T cells, overcome metabolic challenges in the tumor microenvironment (TME), and maximize the benefits of T cell-mediated immunotherapy.

中文翻译：

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一碳代谢塑造癌症 T 细胞免疫力


一碳代谢 （1CM） 包括叶酸代谢和蛋氨酸代谢，是细胞能量供应和重要信号分子（包括单碳部分）产生的重要机制。它的调节有助于维持癌细胞的增殖和促进转移;此外，最近的研究揭示了其对 T 细胞介导的免疫疗法疗效的影响。在这篇综述中，我们整合了当前对 1CM 如何影响 T 细胞活化、分化和功能的见解。此外，我们深入研究了在 T 细胞和肿瘤细胞中调节 1CM 的策略，以增强过继转移的 T 细胞的疗效，克服肿瘤微环境 （TME） 中的代谢挑战，并最大限度地发挥 T 细胞介导的免疫疗法的益处。