The prognosis of patients with decompensated cirrhosis is poor, with significantly increased liver-related mortality rates. With the rising tide of decompensated cirrhosis associated with metabolic dysfunction-associated steatotic liver disease (MASLD), the role of metabolic bariatric surgery (MBS) in achieving hepatic recompensation is garnering increasing attention. However, the complexity of preoperative assessment, the risk of postoperative disease recurrence, and the potential for patients to experience surgical complications of the MBS present challenges. In this opinion article we analyze the potential of MBS to induce recompensation in MASLD-related cirrhosis, discuss the mechanisms by which MBS may affect recompensation, and compare the characteristics of different MBS procedures; we highlight the therapeutic potential of MBS in MASLD-related cirrhosis recompensation and advocate for research in this complex area.

中文翻译：

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通过代谢减肥手术对 MASLD 相关肝硬化进行补偿。


失代偿性肝硬化患者的预后较差，肝脏相关死亡率显着增加。随着与代谢功能障碍相关的脂肪肝病（MASLD）相关的失代偿性肝硬化的兴起，代谢减肥手术（MBS）在实现肝脏再代偿中的作用越来越受到关注。然而，术前评估的复杂性、术后疾病复发的风险以及患者出现 MBS 手术并发症的可能性提出了挑战。在这篇观点文章中，我们分析了 MBS 在 MASLD 相关肝硬化中诱导再补偿的潜力，讨论了 MBS 可能影响再补偿的机制，并比较了不同 MBS 程序的特点；我们强调 MBS 在 MASLD 相关肝硬化再补偿中的治疗潜力，并倡导在这一复杂领域进行研究。