Current brain tumor treatments are limited by the skull and BBB, leading to poor prognosis and short survival for glioma patients. We introduce a novel minimally-invasive brain tumor suppression (MIBTS) device combining personalized intracranial electric field therapy with in-situ chemotherapeutic coating. The core of our MIBTS technique is a wireless-ultrasound-powered, chip-sized, lightweight device with all functional circuits encapsulated in a small but efficient "Swiss-roll" structure, guaranteeing enhanced energy conversion while requiring tiny implantation windows ( ~ 3 × 5 mm), which favors broad consumers acceptance and easy-to-use of the device. Compared with existing technologies, competitive advantages in terms of tumor suppressive efficacy and therapeutic resolution were noticed, with maximum ~80% higher suppression effect than first-line chemotherapy and 50-70% higher than the most advanced tumor treating field technology. In addition, patient-personalized therapy strategies could be tuned from the MIBTS without increasing size or adding circuits on the integrated chip, ensuring the optimal therapeutic effect and avoid tumor resistance. These groundbreaking achievements of MIBTS offer new hope for controlling tumor recurrence and extending patient survival.

中文翻译：

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微创植入式装置可增强脑癌抑制。


目前的脑肿瘤治疗受到颅骨和 BBB 的限制，导致胶质瘤患者预后不良且生存期短。我们推出了一种新型微创脑肿瘤抑制 （MIBTS） 装置，将个性化颅内电场治疗与原位化疗涂层相结合。我们的 MIBTS 技术的核心是一种无线超声供电、芯片大小的轻量级设备，所有功能电路都封装在一个小而高效的“Swiss-roll”结构中，保证了增强的能量转换，同时需要微小的植入窗口（~ 3 × 5 毫米），这有利于广泛的消费者接受和易于使用的设备。与现有技术相比，在肿瘤抑制疗效和治疗分辨率方面具有竞争优势，抑制效果比一线化疗高 ~80%，比最先进的肿瘤治疗野技术高 50-70%。此外，可以从 MIBTS 调整患者个性化的治疗策略，而无需增加尺寸或在集成芯片上添加电路，从而确保最佳治疗效果并避免肿瘤耐药。MIBTS 的这些开创性成就为控制肿瘤复发和延长患者生存期提供了新的希望。