Cardiometabolic disease has become a major health burden worldwide, with sharply increasing prevalence but highly limited therapeutic interventions. Emerging evidence has revealed that arachidonic acid derivatives and pathway factors link metabolic disorders to cardiovascular risks and intimately participate in the progression and severity of cardiometabolic diseases. In this review, we systemically summarized and updated the biological functions of arachidonic acid pathways in cardiometabolic diseases, mainly focusing on heart failure, hypertension, atherosclerosis, nonalcoholic fatty liver disease, obesity, and diabetes. We further discussed the cellular and molecular mechanisms of arachidonic acid pathway-mediated regulation of cardiometabolic diseases and highlighted the emerging clinical advances to improve these pathological conditions by targeting arachidonic acid metabolites and pathway factors.

中文翻译：

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花生四烯酸途径在心脏代谢疾病中的新作用和治疗应用。


心脏代谢疾病已成为全世界的主要健康负担，患病率急剧上升，但治疗干预措施却非常有限。新的证据表明，花生四烯酸衍生物和途径因子将代谢紊乱与心血管风险联系起来，并密切参与心脏代谢疾病的进展和严重程度。本文系统总结并更新了花生四烯酸通路在心脏代谢疾病中的生物学功能，主要关注心力衰竭、高血压、动脉粥样硬化、非酒精性脂肪肝、肥胖和糖尿病等。我们进一步讨论了花生四烯酸途径介导的心脏代谢疾病调节的细胞和分子机制，并强调了通过靶向花生四烯酸代谢物和途径因子来改善这些病理状况的新兴临床进展。