Addressing osteoporosis‐related bone defects, a supramolecular strategy is innovated for modifying carbon fiber reinforced polyether ether ketone (CF/PEEK) composites. By covalently attaching intelligent macromolecules via in situ RAFT polymerization, leveraging the unique pathological microenvironment in patients with iron‐overloaded osteoporosis, intelligent supramolecular modified implant surface possesses multiple endogenous modulation capabilities. After implantation, surface brush‐like macromolecules initially resist macrophage adhesion, thereby reducing the level of immune inflammation. Over time, the molecular chains undergo conformational changes due to Fe (III) mediated supramolecular self‐assembly, transforming into mechanistic signals. These signals are then specifically transmitted to pre‐osteoblast cell through the binding capacity of the KRSR short peptide at the molecular terminus, induced their osteogenic differentiation via the YAP/β‐catenin signaling axis. Furthermore, osteoblasts secrete alkaline phosphatase (ALP), which significantly hydrolyzes phosphate ester bonds in surface macromolecular side groups, resulting in the release of alendronate (ALN). This process further improves the local osteoporotic microenvironment. This intelligent surface modification tailors bone repair to individual conditions, automatically realize multiple endogenous regulation once implanted, and truly realize spontaneous activation of a series of responses conducive to bone repair in vivo. It is evidenced by improved bone regeneration in iron‐overloaded osteoporotic rabbits and supported by in vitro validations.

中文翻译：

---

植入物的智能超分子修饰：骨质疏松症骨缺损修复的内源性调节


为了解决与骨质疏松症相关的骨缺陷，创新了一种超分子策略来改性碳纤维增强聚醚醚酮（CF/PEEK）复合材料。通过原位RAFT聚合共价连接智能大分子，利用铁超载骨质疏松症患者独特的病理微环境，智能超分子修饰种植体表面具有多种内源性调节能力。植入后，表面刷状大分子最初抵抗巨噬细胞粘附，从而降低免疫炎症水平。随着时间的推移，由于 Fe (III) 介导的超分子自组装，分子链发生构象变化，转化为机械信号。然后这些信号通过分子末端KRSR短肽的结合能力特异性传递至前成骨细胞，通过YAP/β-catenin信号轴诱导其成骨分化。此外，成骨细胞分泌碱性磷酸酶（ALP），显着水解表面大分子侧基中的磷酸酯键，导致阿仑膦酸钠（ALN）的释放。这一过程进一步改善了局部骨质疏松微环境。这种智能表面修饰根据个体情况量身定制骨修复，植入后自动实现多重内源性调节，真正实现体内一系列有利于骨修复的反应的自发激活。铁超载骨质疏松兔子的骨再生改善证明了这一点，并得到体外验证的支持。