Landmark studies have shown decreased coherence between different emotion response systems (e.g., physiology and facial expressions) in people with psychosis. However, while there is good evidence to suggest broad signs of affective dysfunction (e.g., blunting of facial expression) in the critical clinical high-risk (CHR) state, it is not clear whether these signs fit into a broader pattern of decoupling. This is in part due to there being no studies to date with this population that include a dyadic interaction. The current laboratory-based dyadic interaction study examined whether there is decreased coherence in CHR between autonomic physiology, as indexed by heart rate, and facial expressions of emotion, assessed by automated facial expressions analysis. The study included 145 individuals consisting of 34 CHR-partner and 41 control-partner pairs who completed clinical interviews and engaged in three naturalistic 10-min conversations while their physiology and expressions were continuously monitored. Compared to controls, CHR youth showed decreased coherence between heart rate and positive (t = 4.09) and negative (t = -7.90) facial expressions. Across CHR and control youth, greater severity of psychosis risk symptoms was related to lower coherence between heart rate and positive (t = 3.97-11.69) and neutral expressions (t = 0.06-4.98), and a change in the direction of the relationship between heart rate and negative expression intensity (t = 7.88-10.60). These findings provide the first evidence for changes in coherence between physiology and facial expressions of emotion in CHR individuals, with larger changes in coherence relating to greater general psychotic-like symptom severity. This evidence may be leveraged to identify targets for early diagnosis and intervention. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

中文翻译：

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临床精神病高风险个体自主激活和情绪表达之间的一致性被破坏。


具有里程碑意义的研究表明，精神病患者不同情绪反应系统（例如生理和面部表情）之间的一致性降低。然而，虽然有充分的证据表明在关键的临床高风险（CHR）状态下存在情感功能障碍的广泛迹象（例如面部表情迟钝），但尚不清楚这些迹象是否符合更广泛的脱钩模式。部分原因是迄今为止还没有针对这一人群的研究包含二元相互作用。目前基于实验室的二元相互作用研究检查了自主生理学（以心率为索引）与情绪面部表情（通过自动面部表情分析评​​估）之间的 CHR 一致性是否降低。该研究包括 145 个人，其中包括 34 组 CHR 伴侣和 41 组对照伴侣，他们完成了临床访谈并进行了 3 场 10 分钟的自然对话，同时持续监测他们的生理和表情。与对照组相比，CHR 青少年心率与积极 (t = 4.09) 和消极 (t = -7.90) 面部表情之间的一致性降低。在 CHR 和对照组青少年中，精神病风险症状的严重程度与心率与阳性表达 (t = 3.97-11.69) 和中性表达 (t = 0.06-4.98) 之间的一致性较低有关，并且与心率之间关系方向的变化有关。心率和阴性表达强度（t = 7.88-10.60）。这些发现为 CHR 个体的生理和情绪面部表情之间的一致性变化提供了第一个证据，一致性的较大变化与一般精神病样症状的严重程度有关。 这些证据可用于确定早期诊断和干预的目标。 （PsycInfo 数据库记录 (c) 2024 APA，保留所有权利）。