The SAGA complex is an evolutionarily conserved histone acetyltransferase complex and transcription coactivator essential for development and disease. Dysregulation of SAGA is implicated in various human diseases, including cancer. In this issue of Genes & Development, Chen et al. (doi:10.1101/gad.351789.124) uncover a critical role for SAGA in multiple myeloma wherein SAGA's ADA2B component is required for the expression of mTORC1 pathway genes and targets of the MYC, E2F, and MAF (musculoaponeurotic fibrosarcoma) transcription factors. SAGA cooperates with MYC and MAF to sustain oncogenic gene expression programs vital for multiple myeloma survival and thus may serve as a therapeutic target for future cancer therapies.

中文翻译：

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MYC-MAF-SAGA 轴驱动多发性骨髓瘤中的致癌基因表达


SAGA 复合物是一种进化上保守的组蛋白乙酰转移酶复合物，也是发育和疾病所必需的转录共激活因子。SAGA 的失调与各种人类疾病有关，包括癌症。在本期的基因与发展中，Chen等人（doi：10.1101/gad.351789.124）揭示了SAGA在多发性骨髓瘤中的关键作用，其中SAGA的ADA2B成分对于表达mTORC1通路基因和MYC、E2F和MAF（肌肉腱膜纤维肉瘤）转录因子的目标是必需的。SAGA 与 MYC 和 MAF 合作，维持对多发性骨髓瘤生存至关重要的致癌基因表达项目，因此可能作为未来癌症治疗的治疗靶点。