Intracellular metabolism is a crucial regulator of macrophage function. Recent evidence revealed that the polyamine pathway and subsequent hypusination of eukaryotic initiation factor 5A (eIF5A) are master regulators of immune cell functions. In brown adipose tissue (BAT), macrophages show an impressive degree of heterogenicity, with specific subsets supporting adaptive thermogenesis during cold exposure. In this review, we discuss the impact of polyamine metabolism on macrophage diversity and function, with a particular focus on their role in adipose tissue homeostasis. Thus, we highlight the exploration of how polyamine metabolism in macrophages contributes to BAT homeostasis as an attractive and exciting new field of research.

中文翻译：

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巨噬细胞-脂肪组织中的多胺代谢功能和稳态


细胞内代谢是巨噬细胞功能的重要调节因子。最近的证据表明，多胺途径和随后的真核起始因子 5A （eIF5A） 的催眠是免疫细胞功能的主要调节因子。在棕色脂肪组织 （BAT） 中，巨噬细胞显示出令人印象深刻的异质性程度，在寒冷暴露期间，特定亚群支持适应性产热。在这篇综述中，我们讨论了多胺代谢对巨噬细胞多样性和功能的影响，特别关注它们在脂肪组织稳态中的作用。因此，我们强调了对巨噬细胞中多胺代谢如何促进 BAT 稳态的探索，这是一个有吸引力且令人兴奋的新研究领域。