BACKGROUND The primary purpose of this two-arm, parallel design, randomized controlled study is to compare healing of the palatal tissue donor site when platelet-rich fibrin (PRF) is used as a wound dressing compared to the use of a hemostatic agent. Secondary outcomes of patient pain perception and analgesic intake were also evaluated. METHODS Seventy-four patients receiving free gingival grafts were randomized to receive either PRF (test) or hemostatic agent (control) as a palatal wound dressing by patients selecting a sealed envelope containing their group assignment (initially 37 envelopes for PRF group and 37 for hemostatic agent group). Patient pain assessment and analgesic consumption were documented using a 21-point numerical scale (NMRS-21) at 24, 48, and 72 hours post-surgery. At 1-, 2-, 3-, and 4-week follow-up appointments palatal early healing index (PEHI) scores including wound color, epithelialization, presence or absence of swelling, granulation tissue, and bleeding on gentle palpation were generated by direct intraoral examination by a blinded examiner unaware of the patients' treatment group. RESULTS NMRS-21 pain scores showed a significant reduction in pain over time in both groups, with no significant difference between groups at any time point. No significant between-group difference was found in the amount of analgesics taken by patients at 24, 48, and 72 hours. There was significant improvement in PEHI scores over the 4-week time period in both groups, but there was no significant difference in PEHI score at each time point (1, 2, 3, 4 weeks) between groups. CONCLUSIONS: Study findings suggest that there is no difference in early palatal wound healing, patient pain perception, or analgesic consumption between use of PRF or a hemostatic agent as donor-site wound dressings.

中文翻译：

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使用富含血小板的纤维蛋白进行游离牙龈移植手术后供体部位伤口愈合：一项随机对照试验。


背景 这项双臂、平行设计、随机对照研究的主要目的是比较使用富含血小板的纤维蛋白 （PRF） 作为伤口敷料与使用止血剂时腭组织供体部位的愈合情况。还评估了患者疼痛感知和镇痛药摄入量的次要结局。方法 74 例接受游离牙龈移植物的患者被随机分配接受 PRF （测试） 或止血剂 （对照） 作为腭伤口敷料，患者选择一个包含其组分配的密封信封 （最初 PRF 组 37 个信封，止血剂组 37 个信封）。在术后 24、48 和 72 小时使用 21 点数字量表 （NMRS-21） 记录患者疼痛评估和镇痛药消耗量。在 1 周、 2 周、 3 周和 4 周的随访预约中，腭早期愈合指数 （PEHI） 评分包括伤口颜色、上皮化、是否存在肿胀、肉芽组织和轻触出血，由不了解患者治疗组的盲法检查者直接口内检查产生。结果 NMRS-21 疼痛评分显示，两组的疼痛随时间显著减轻，在任何时间点组间均无显著差异。未发现患者在 24 、 48 和 72 小时服用镇痛药的组间剂量存在显著差异。两组的 PEHI 评分在 4 周内均有显著改善，但各组之间每个时间点 （1 、 2 、 3 、 4 周） 的 PEHI 评分无显著差异。 结论： 研究结果表明，使用 PRF 或止血剂作为供体部位伤口敷料在早期腭伤口愈合、患者疼痛感知或镇痛药消耗方面没有差异。