BACKGROUND Implant surface decontamination is a critical step in peri-implantitis treatment. The aim of this study was to assess the effect chemotherapeutic agents have on reosseointegration after treatment on ligature-inducted peri-implantitis. METHODS Six male canines had 36 implants placed and ligatures were placed around them for 28 weeks to establish peri-implantitis. The peri-implant defects were randomly treated by 1 of 3 methods: 0.12% chlorhexidine (CHX test group), 1.5% sodium hypochlorite (NaOCl test group), or saline (Control group). Sites treated with NaOCl and CHX were grafted with autogenous bone, and all sites then either received a collagen membrane or not. Histology sections were obtained at 6 months postsurgery to assess percentage of reosseointegration. RESULTS Thirty-five implants were analyzed (CHX: 13; NaOCl: 14; Control:8). NaOCl-treated sites demonstrated reosseointegration with direct bone-to-implant-contact on the previously contaminated surfaces (42% mean reosseointegration), which was significantly higher than Controls (p < 0.05). Correspondingly, clinical improvement was noted with a significant reduction in probing depth from 5.50 ± 1.24 mm at baseline to 4.46 ± 1.70 mm at 6-months postsurgery (p = 0.006). CHX-treated sites demonstrated a nonsignificant reosseointegration of 26% (p > 0.05); however, in the majority of cases, the new bone growth was at a distance from the implant surface without contact. Probing depths did not improve in the CHX group. The use of membrane did not influence reosseointegration or probing depths (all p > 0.05). CONCLUSION Titanium implants with peri-implantitis have the capacity to reosseointegrate following regenerative surgery. However, treatment response is contingent upon the chemotherapeutic agent selection. Additional chemical treatment with 1.5% NaOCl lead to the most favorable results in terms of changes in defect depth and percentage of reosseointegration as compared to CHX, which may hinder reosseointegration.

中文翻译：

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表面化学处理对结扎诱导的种植体周围炎手术再生治疗的影响：犬类研究。


背景 种植体表面去污是种植体周围炎治疗的关键步骤。本研究的目的是评估化疗药物对结扎诱导种植体周围炎治疗后骨结合的影响。方法 6 只雄性犬放置了 36 个植入物，并在它们周围放置结扎线 28 周以建立种植体周围炎。种植体周围缺损采用 3 种方法中的一种随机处理： 0.12% 氯己定 （CHX 试验组） 、1.5% 次氯酸钠 （NaOCl 试验组） 或生理盐水 （对照组）。用 NaOCl 和 CHX 处理的部位用自体骨移植，然后所有部位要么接受胶原膜，要么不接受。术后 6 个月获取组织学切片，以评估骨整合百分比。结果 分析了 35 个种植体 （CHX： 13;NaOCl：14;Control：8）。NaOCl 处理部位表现出骨整合，在先前受污染的表面上骨与植入物直接接触 （42% 平均骨整合），这显着高于对照组 （p < 0.05）。相应地，临床改善，探诊深度从基线的 5.50 ± 1.24 毫米显着减少到术后 6 个月的 4.46 ± 1.70 毫米 （p = 0.006）。CHX 处理部位显示 26% 的不显著骨整合 （p > 0.05）;然而，在大多数情况下，新骨生长在远离种植体表面的地方，没有接触。CHX 组的探查深度没有改善。膜的使用不影响骨整合或探查深度 （均 p > 0.05）。结论 伴种植体周围炎的钛植入物在再生手术后具有骨整合能力。 然而，治疗反应取决于化疗药物的选择。与 CHX 相比，使用 1.5% NaOCl 的额外化学处理在缺损深度和骨整合百分比的变化方面产生最有利的结果，这可能会阻碍骨整合。