Eukaryotic and archaeal translation initiation factor 2 in complex with GTP delivers the initiator methionyl-tRNA to the small ribosomal subunit. Over the past 20 years, thanks to the efforts of various research groups, including ours, this factor from the archaeon Sulfolobus solfataricus and its individual subunits have been crystallized in ten different space groups. Analysis of the molecular packing in these crystals makes it possible to better understand the roles of functionally significant switches and other elements of the nucleotide-binding pocket during the function of the factor as well as the influence of external effects on its transition between active and inactive states.

中文翻译：

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翻译起始因子 2 的晶体堆积分析揭示了其功能的新细节。


真核和古细菌翻译起始因子 2 与 GTP 复合，将起始子甲硫氨酰-tRNA 传递至小核糖体亚基。过去20年来，在包括我们在内的各个研究小组的努力下，来自古细菌硫磺叶菌及其各个亚基的这一因子已在十个不同的空间群中结晶。通过分析这些晶体中的分子堆积，可以更好地了解功能上重要的开关和核苷酸结合袋的其他元件在因子功能过程中的作用，以及外部效应对其活性和非活性之间转变的影响。州。