Immunometabolism is an emerging field at the intersection of immunology and metabolism. Immune cell activation plays a critical role in the pathogenesis of cardiovascular diseases and is integral for regeneration during cardiac injury. We currently possess a limited understanding of the processes governing metabolic interactions between immune cells and cardiomyocytes. The impact of this intercellular crosstalk can manifest as alterations to the steady state flux of metabolites and impact cardiac contractile function. Although much of our knowledge is derived from acute inflammatory response, recent work emphasizes heterogeneity and flexibility in metabolism between cardiomyocytes and immune cells during pathological states, including ischemic, cardiometabolic, and cancer-associated disease. Metabolic adaptation is crucial because it influences immune cell activation, cytokine release, and potential therapeutic vulnerabilities. This review describes current concepts about immunometabolic regulation in the heart, focusing on intercellular crosstalk and intrinsic factors driving cellular regulation. We discuss experimental approaches to measure the cardio-immunologic crosstalk, which are necessary to uncover unknown mechanisms underlying the immune and cardiac interface. Deeper insight into these axes holds promise for therapeutic strategies that optimize cardioimmunology crosstalk for cardiac health.

中文翻译：

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心肌疾病免疫学和代谢的交叉点。


免疫代谢是免疫学和代谢学交叉领域的一个新兴领域。免疫细胞活化在心血管疾病的发病机制中起着关键作用，是心脏损伤期间再生不可或缺的一部分。我们目前对控制免疫细胞和心肌细胞之间代谢相互作用的过程了解有限。这种细胞间串扰的影响可以表现为代谢物稳态通量的改变，并影响心脏收缩功能。尽管我们的大部分知识来自急性炎症反应，但最近的工作强调心肌细胞和免疫细胞在病理状态（包括缺血、心脏代谢和癌症相关疾病）期间代谢的异质性和灵活性。代谢适应至关重要，因为它会影响免疫细胞活化、细胞因子释放和潜在的治疗脆弱性。本综述描述了当前关于心脏免疫代谢调节的概念，重点介绍细胞间串扰和驱动细胞调节的内在因素。我们讨论了测量心脏免疫串扰的实验方法，这对于揭示免疫和心脏接口的未知机制是必要的。更深入地了解这些轴有望为优化心脏免疫学串扰以促进心脏健康的治疗策略带来希望。