Exploiting the pH-Cross Sensitivity of Ion-Selective Optodes to Broaden Their Response Range,ACS Sensors

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Exploiting the pH-Cross Sensitivity of Ion-Selective Optodes to Broaden Their Response Range
ACS Sensors ( IF 8.2 ) Pub Date : 2024-08-22 , DOI: 10.1021/acssensors.4c01481
Fabian Steininger ₁ , Johan Palmfeldt ₂ , Klaus Koren ₁ , Andrey V Kalinichev ₁

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While the pH cross-sensitivity of chromoionophore-based ion-selective optodes (ISOs) has often been regarded as a significant limitation, this paper demonstrates how this apparent drawback can be transformed into a beneficial feature. The response range of chromoionophore-based ISOs shifts proportionally with changes in the sample pH. Thus, integrating them with a stable pH gradient across the optode surface, such as those provided by immobilized pH gradient (IPG) gels, allows for significant enhancement of the effective measuring range of chromoionophore-based ISOs while preserving their maximum sensitivity. We show that the measuring range of sodium-selective chromoionophore-based optodes can be increased up to 2.5 log units when used with commercially available IPG gels. This improvement in measuring range is directly correlated with the pH difference in the pH gradient across the optode, suggesting that even greater enhancements are possible with more substantial pH gradients. Furthermore, this approach is not confined to sodium-selective optodes but can be readily adapted to other ion-selective chromoionophore-based optodes, broadening their potential applications and impact in the field of chemical sensing. This work paves the way for the development of more versatile and highly sensitive optodes across a broad range of analytes, leveraging the pH cross-sensitivity as a tool for enhanced performance.

中文翻译：

利用离子选择性光电器件的 pH 交叉敏感性来拓宽其响应范围

虽然基于发色离子载体的离子选择性光极 (ISO) 的 pH 交叉敏感性通常被认为是一个重大限制，但本文演示了如何将这一明显的缺点转化为有益的特征。基于发色离子载体的 ISO 的响应范围随样品 pH 值的变化成比例地变化。因此，将它们与光极表面上稳定的 pH 梯度（例如由固定 pH 梯度 (IPG) 凝胶提供的梯度）相结合，可以显着增强基于发色离子载体的 ISO 的有效测量范围，同时保持其最大灵敏度。我们证明，当与市售 IPG 凝胶一起使用时，基于钠选择性发色离子载体的光极的测量范围可增加至 2.5 个对数单位。测量范围的这种改进与整个光极的 pH 梯度的 pH 差异直接相关，表明更大的 pH 梯度可能会带来更大的增强。此外，这种方法不仅限于钠选择性光极，还可以很容易地适用于其他基于离子选择性发色团的光极，扩大其在化学传感领域的潜在应用和影响。这项工作为开发适用于多种分析物的更通用且高灵敏度的光极铺平了道路，利用 pH 交叉敏感性作为增强性能的工具。

更新日期：2024-08-22

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