Inhibitors of the Cyclic GMP-AMP Synthase (cGAS) as Potential Treatment for Autoimmune and Inflammatory Diseases,ACS Medicinal Chemistry Letters

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Inhibitors of the Cyclic GMP-AMP Synthase (cGAS) as Potential Treatment for Autoimmune and Inflammatory Diseases
ACS Medicinal Chemistry Letters ( IF 3.5 ) Pub Date : 2024-08-22 , DOI: 10.1021/acsmedchemlett.4c00392
Ahmed F Abdel-Magid ₁

Affiliation

The invention in this patent application relates to macrocyclic benzimidazole derivatives represented herein generally by Formula 1. The compounds of Formula 1 are cGAS inhibitors and may potentially provide treatments of autoimmune diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), interferonopathies, and others.

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