The use of chimeric antigen receptor T (CAR-T) cells is a significant therapeutic improvement increasing the prognosis for patients with a variety of hematological malignancies. However, this therapy has also sometimes life-threatening, complications. Therefore, knowledge of the treatment and management of these complications, especially in treatment centers and intensive care units, respectively, is of outstanding importance. This review provides recommendations for the diagnosis, management, and treatment of CAR-T cell-associated complications such as cytokine release syndrome, immune effector cell associated neurotoxicity syndrome, hematotoxicity, hypogammaglobulinemia, and CAR-T cell-induced pseudo-progression amongst others for physicians treating patients with CAR-T cell-associated complications and intensivists.

嵌合抗原受体 T （CAR-T） 细胞的使用是一种显着的治疗改善，可改善各种血液系统恶性肿瘤患者的预后。然而，这种疗法有时也会出现危及生命的并发症。因此，了解这些并发症的治疗和管理，尤其是分别在治疗中心和重症监护病房，非常重要。本综述为治疗 CAR-T 细胞相关并发症的医生和重症监护医师提供了 CAR-T 细胞相关并发症的诊断、管理和治疗建议，例如细胞因子释放综合征、免疫效应细胞相关神经毒性综合征、血液毒性、低丙种球蛋白血症和 CAR-T 细胞诱导的假性进展等。