Pancreatic β-cells do not appear to require interactions with neighbouring non-β-cells (α-cells, δ-cells and γ-cells) to regulate insulin secretion. These results are clinically relevant and support the development of treatments for diabetes that involve the generation of β-like cells alone, whether from pluripotent cells or by in situ conversion of non-β-cells.

中文翻译：

---

调节仅由 β 细胞组成的人和小鼠胰岛的胰岛素分泌


胰腺 β 细胞似乎不需要与邻近的非 β 细胞（α 细胞、δ 细胞和 γ 细胞）相互作用来调节胰岛素分泌。这些结果具有临床相关性，并支持开发仅涉及β样细胞生成的糖尿病治疗方法，无论是通过多能细胞还是通过非β细胞的原位转化。