Reversible Fluorescent Probes for Dynamic Imaging of Liver Ischemia-Reperfusion Injury,Accounts of Chemical Research

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Reversible Fluorescent Probes for Dynamic Imaging of Liver Ischemia-Reperfusion Injury
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2024-08-20 , DOI: 10.1021/acs.accounts.4c00449
Wen Zhang ₁ , Jihong Liu _{1,

2} , Ping Li _{1,

3} , Xin Wang ₁ , Bo Tang _{1,

4}

Affiliation

Hepatic ischemia-reperfusion injury (HIRI) is an inevitable complication of clinical surgeries such as liver resection or transplantation, often resulting in postoperative liver dysfunction, hepatic failure in up to 13% of postresection patients, and early graft failure in 11–18% of liver transplantation patients. HIRI involves a series of biochemical events triggered by abnormal alterations in multiple biomarkers, characterized by short lifespans, dynamic changes, subcellular regional distribution, and multicollaborative regulation. However, traditional diagnosis, including serology, imaging, and liver puncture biopsy, suffers from low sensitivity, poor resolution, and hysteresis, which hinder effective monitoring of HIRI markers. Thus, to address the unique properties of HIRI markers, there is a pressing demand for developing novel detection strategies that are highly selective, transiently responsive, dynamically reversible, subcellular organelle-targeted, and capable of simultaneous multicomponent analysis.

中文翻译：

用于肝脏缺血再灌注损伤动态成像的可逆荧光探针

肝缺血再灌注损伤（HIRI）是肝切除或移植等临床手术不可避免的并发症，常常导致术后肝功能障碍，高达 13% 的术后患者出现肝功能衰竭，11-18% 的患者出现早期移植失败。肝移植患者。 HIRI涉及多种生物标志物异常改变引发的一系列生化事件，具有寿命短、动态变化、亚细胞区域分布和多协同调控等特点。然而，传统诊断，包括血清学、影像学、肝穿刺活检等，存在灵敏度低、分辨率差、滞后等问题，阻碍了HIRI标志物的有效监测。因此，为了解决 HIRI 标记的独特特性，迫切需要开发新的检测策略，这些策略具有高选择性、瞬时响应、动态可逆、亚细胞器靶向且能够同时进行多组分分析。

更新日期：2024-08-20

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