Colorimetric Detection of Aqueous N-Nitrosodimethylamine via Photonitrosation of a Naphtholsulfonate Indicator,ACS Sensors

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Colorimetric Detection of Aqueous N-Nitrosodimethylamine via Photonitrosation of a Naphtholsulfonate Indicator
ACS Sensors ( IF 8.2 ) Pub Date : 2024-08-21 , DOI: 10.1021/acssensors.4c00927
Jessica C Beard ₁ , Chi-Hsien Wang ₁ , Arun Sridharan ₁ , Robert G Croy ₂ , John M Essigmann _{1,

2} , Timothy M Swager ₁

Affiliation

N-Nitrosamines are contaminants found throughout the environment, including in drinking water, and many nitrosamines are likely potent carcinogens. Correspondingly, there is a need for rapid and cost-effective in-field detection methods that can provide timely information about their contamination levels in water. This study details a colorimetric assay for detecting aqueous N-nitrosodimethylamine (NDMA) by photochemical nitrosation of a commercial naphtholsulfonate, to offer an attractive alternative to traditional laboratory-based analysis. The resulting naphthoquinone-oxime coordinates to aqueous iron(II) ions to form a green complex, allowing for direct visual detection. Characterization via Mössbauer and electron paramagnetic resonance (EPR) spectroscopy, alongside single-crystal structure determination, provides comprehensive structure information on the iron indicator complex. Optimization of detection conditions, including UV irradiation and response times, led to an improved colorimetric detection method with a limit of detection of 0.66 ppm for NDMA. The practical applicability and selectivity of this colorimetric detection scheme make it a promising candidate for the development of field-deployable sensors for NDMA in environmental water samples.

中文翻译：

通过萘酚磺酸盐指示剂的光亚硝化对 N-亚硝基二甲胺水溶液进行比色检测

N-亚硝胺是在整个环境（包括饮用水）中发现的污染物，许多亚硝胺可能是强效致癌物。相应地，需要快速且经济高效的现场检测方法，能够及时提供有关水中污染物水平的信息。这项研究详细介绍了一种通过商业萘酚磺酸盐的光化学亚硝化来检测水性N-亚硝基二甲胺 (NDMA) 的比色测定法，为传统的实验室分析提供了一种有吸引力的替代方案。所得萘醌肟与水性铁 (II) 离子配位形成绿色复合物，可直接进行视觉检测。通过穆斯堡尔和电子顺磁共振 (EPR) 光谱进行表征以及单晶结构测定，可提供铁指示剂复合物的全面结构信息。检测条件（包括紫外线照射和响应时间）的优化改进了比色检测方法，NDMA 的检测限为 0.66 ppm。这种比色检测方案的实际适用性和选择性使其成为开发环境水样中 NDMA 现场部署传感器的有希望的候选者。

更新日期：2024-08-21

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