An account of the current status of point-of-care lateral flow tests for kidney biomarker detection,Analyst

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An account of the current status of point-of-care lateral flow tests for kidney biomarker detection
Analyst ( IF 3.6 ) Pub Date : 2024-08-19 , DOI: 10.1039/d4an00806e
Tileshwar Sahare ₁ , Badri Narayana Sahoo ₁ , Surbhi Jaiswal ₁ , Simran Rana ₁ , Abhijeet Joshi ₁

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Globally, the primary causes of mortality and morbidity related to kidney ailments can be classified as Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD). Biomarker detection can have great potential to improve survival, lower mortality, and reduce the cost of treatment of kidney diseases. Considering the chronic nature of CKD, non-invasive identification and monitoring have proven to be useful. Biosensors and more specifically lateral flow test strips (LFTs) are regarded as the most desirable point-of-care instruments which have shown promise in elevating the healthcare industry to a new level. The major aspects of an ideal point-of-care (POC) lateral flow test include its cost effectiveness, high sensitivity and specificity, ease of use, quick result delivery, and quality control. This review provides a detailed account of recent developments, challenges, and opportunities in renal biomarker detection using LFTs including various approaches for sensitivity enhancement along with potential future advancements in POC and LFT kits.

中文翻译：

肾脏生物标志物检测的即时侧流检测的现状

在全球范围内，与肾脏疾病相关的死亡和发病的主要原因可分为急性肾损伤（AKI）和慢性肾脏病（CKD）。生物标志物检测在提高生存率、降低死亡率和降低肾脏疾病的治疗成本方面具有巨大潜力。考虑到 CKD 的慢性性质，非侵入性识别和监测已被证明是有用的。生物传感器，更具体地说是侧向层析测试条 (LFT) 被认为是最理想的护理点仪器，它已显示出将医疗保健行业提升到新水平的前景。理想的即时护理 (POC) 侧流检测的主要方面包括成本效益、高灵敏度和特异性、易用性、快速结果交付和质量控制。本综述详细介绍了使用 LFT 进行肾脏生物标志物检测的最新进展、挑战和机遇，包括各种增强灵敏度的方法以及 POC 和 LFT 试剂盒未来潜在的进展。

更新日期：2024-08-19

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