The therapeutic principle of allogeneic hematopoietic cell transplantation, one the most common forms of cancer immunotherapy, is alloreactivity, yet its molecular determinants remain largely unknown. An analytical framework now enables personalized assessment of alloreactivity from whole-exome sequencing of donor–recipient pairs, to help with prognostication of disease relapse and immune-mediated complications.

中文翻译：

---

预测造血细胞移植同种异体反应性的框架


同种异体造血细胞移植是癌症免疫治疗最常见的形式之一，其治疗原理是同种异体反应性，但其分子决定因素仍然很大程度上未知。现在，一个分析框架可以根据供体-受体对的全外显子组测序对同种异体反应性进行个性化评估，以帮助预测疾病复发和免疫介导的并发症。