We have discovered an effect, termed stacking-induced intermolecular charge transfer-enhanced Raman scattering (SICTERS), that enhances the Raman signal intensities of small molecules by relying on their self-stacking rather than external substrates. This effect enables the design of substrate-free small-molecule probes for high-resolution, non-invasive transdermal Raman imaging of lymphatic drainage and microvessels.

中文翻译：

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小分子有序自组织增强拉曼信号


我们发现了一种称为堆叠诱导分子间电荷转移增强拉曼散射（SICTERS）的效应，它通过依赖小分子的自堆叠而不是外部基质来增强小分子的拉曼信号强度。这种效应使得能够设计无基质小分子探针，用于淋巴引流和微血管的高分辨率、非侵入性经皮拉曼成像。