Serum neurofilament light at diagnosis: a prognostic indicator for accelerated disease progression in Parkinson’s Disease,npj Parkinson's Disease

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Serum neurofilament light at diagnosis: a prognostic indicator for accelerated disease progression in Parkinson’s Disease
npj Parkinson's Disease ( IF 6.7 ) Pub Date : 2024-08-21 , DOI: 10.1038/s41531-024-00768-1
Camilla Christina Pedersen _{1,

2} , Anastasia Ushakova ₃ , Guido Alves _{1,

2,

4} , Ole-Bjørn Tysnes _{5,

6} , Kaj Blennow _{7,

8,

9,

10} , Henrik Zetterberg _{7,

8,

11,

12,

13,

14} , Jodi Maple-Grødem _{1,

2} , Johannes Lange _{1,

2}

Affiliation

The Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway.
Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway.
Section of Biostatistics, Department of Research, Stavanger University Hospital, Stavanger, Norway.
Department of Neurology, Stavanger University Hospital, Stavanger, Norway.
Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Department of Neurology, Haukeland University Hospital, Bergen, Norway.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.
Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, P.R. China.
Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
UK Dementia Research Institute at UCL, London, UK.
Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Neurofilament light chain (NFL) is elevated in neurodegenerative diseases, including Parkinson’s disease (PD). This study aimed to investigate serum NFL in newly diagnosed PD and its association with cognitive and motor decline over 10 years. Serum NFL levels were measured in PD patients and controls from the ParkWest study at diagnosis (baseline) and after 3 and 5 years. Mixed-effects regression analyzed changes in NFL and the association with annual changes in MMSE and UPDRS-III scores over 10 years. PD patients had elevated serum NFL at all visits and a faster annual increase over 5 years compared to controls (0.09 pg/mL per year; p = 0.029). Higher baseline NFL predicted faster cognitive decline β −0.77 transformed MMSE; p = 0.010), and a 40% NFL increase predicted future motor decline (β 0.28 UPDRS-III; p = 0.004). Elevated serum NFL in early PD is linked to faster cognitive and motor impairment, suggesting its prognostic value in PD biomarker panels.

中文翻译：

诊断时血清神经丝光：帕金森病加速疾病进展的预后指标

神经丝轻链 (NFL) 在神经退行性疾病中升高，包括帕金森病 (PD)。本研究旨在调查新诊断 PD 的血清 NFL 及其与 10 年来认知和运动能力下降的关系。 ParkWest 研究中在诊断时（基线）以及 3 和 5 年后测量了 PD 患者和对照组的血清 NFL 水平。混合效应回归分析了 NFL 的变化以及 10 年来 MMSE 和 UPDRS-III 评分每年变化的关联。 PD 患者在每次就诊时血清 NFL 均升高，并且与对照组相比，5 年内每年升高速度更快（每年 0.09 pg/mL； p = 0.029）。较高的基线 NFL 预测较快的认知衰退 β -0.77 转换后的 MMSE； p = 0.010），40% NFL 增加预测未来运动能力下降（β 0.28 UPDRS-III； p = 0.004）。早期帕金森病中血清 NFL 升高与更快的认知和运动障碍有关，表明其在帕金森病生物标志物组中的预后价值。

更新日期：2024-08-21

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