Alzheimer's disease (AD), the leading cause of dementia, is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. This condition casts a significant shadow on global health due to its complex and multifactorial nature. In addition to genetic predispositions, the development of AD is influenced by a myriad of risk factors, including aging, systemic inflammation, chronic health conditions, lifestyle and environmental exposures. Recent advancements in understanding the complex pathophysiology of AD are paving the way for enhanced diagnostic techniques, improved risk assessment, and potentially effective prevention strategies. These discoveries are crucial in the quest to unravel the complexities of AD, offering a beacon of hope for improved management and treatment options for the millions affected by this debilitating disease.

中文翻译：

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阿尔茨海默病：深入了解病理学、分子机制和治疗。


阿尔茨海默病 (AD) 是痴呆症的主要原因，其特征是大脑中淀粉样斑块和神经原纤维缠结的积累。由于其复杂性和多因素性，这种情况给全球健康带来了重大阴影。除了遗传倾向外，AD 的发展还受到多种危险因素的影响，包括衰老、全身炎症、慢性健康状况、生活方式和环境暴露。最近在了解 AD 复杂的病理生理学方面取得的进展，为增强诊断技术、改进风险评估和潜在有效的预防策略铺平了道路。这些发现对于解开 AD 的复杂性至关重要，为改善数百万受这种衰弱性疾病影响的管理和治疗方案提供了希望。