The mechanisms driving sex differences in immunity are poorly understood and likely vary by body site; thus Chi et al. investigated the mechanistic basis of sex differences in tissue-specific immunity in a recent paper in Science. They focused on the complex network of immune cells in murine skin to demonstrate that an androgen-ILC2-dendritic cell axis drives sex differences in immune homeostasis in the skin that is modulated by sex-differential microbiota.

中文翻译：

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ILC2 控制皮肤的性别差异免疫

人们对造成免疫力性别差异的机制知之甚少，并且可能因身体部位而异；因此 Chi 等人。最近在《科学》杂志上发表的一篇论文研究了组织特异性免疫性别差异的机制基础。他们专注于小鼠皮肤中免疫细胞的复杂网络，以证明雄激素-ILC2-树突状细胞轴驱动皮肤中免疫稳态的性别差异，而这种差异是由性别差异微生物群调节的。