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Associations of Relative Intensity of Physical Activity With Incident Cardiovascular Events and All-Cause Mortality
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences ( IF 4.3 ) Pub Date : 2024-05-03 , DOI: 10.1093/gerona/glae113
Benjamin T Schumacher 1 , Michael J LaMonte 2 , Chongzhi Di 3 , Humberto Parada 4, 5 , Steven P Hooker 6 , John Bellettiere 1 , Eleanor M Simonsick 7 , Sandy Liles 1, 8 , Andrea Z LaCroix 1
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Background The relative intensity of physical activity (PA) can be estimated as the percent of one’s maximal effort required. Methods We compared associations of relative and absolute intensity PA with incident major cardiovascular disease (CVD) and all-cause mortality in 5 633 women from the Objective Physical Activity and Cardiovascular Health Study (mean age 78.5 ± 6.7). Absolute intensity was measured by accelerometry. Relative intensity was estimated by dividing accelerometer-estimated metabolic equivalents (METs) by maximal MET capacity. Both were aggregated into mean daily hours of light intensity PA (LPA) and moderate-to-vigorous PA (MVPA). Cox proportional hazard models estimated hazard ratios (HRs) for 1-hour higher amounts of PA on outcomes. Results During follow-up (median = 7.4 years), there were 748 incident CVD events and 1 312 deaths. Greater LPA and MVPA, on either scale, were associated with reduced risk of both outcomes. HRs for a 1-hour increment of absolute LPA were 0.88 (95% CI: 0.83–0.93) and 0.88 (95% CI: 0.84–0.92) for incident CVD and mortality, respectively. HRs for a 1-hour increment of absolute MPVA were 0.73 (95% CI: 0.61–0.87) and 0.55 (95% CI: 0.48–0.64) for the same outcomes. HRs for a 1-hour increment of relative LPA were 0.70 (95% CI: 0.59–0.84) and 0.78 (95% CI: 0.68–0.89) for incident CVD and mortality, respectively. HRs for a 1-hour increment of relative MPVA were 0.89 (95% CI: 0.83–0.96) and 0.82 (95% CI: 0.77–0.87) for the same outcomes. On the relative scale, LPA was more strongly, and inversely associated with both outcomes than relative MVPA. Absolute MVPA was more strongly inversely associated with the outcomes than relative MVPA. Conclusions Findings support the continued shift in the PA intensity paradigm toward recommendation of more movement, regardless of intensity. Relative LPA––a modifiable, more easily achieved behavioral target, particularly among ambulatory older adults––was associated with reduced risk of incident major CVD and death.

中文翻译:


身体活动的相对强度与心血管事件和全因死亡率的相关性



背景 体力活动的相对强度 (PA) 可以估计为一个人所需的最大努力的百分比。方法 我们比较了客观身体活动和心血管健康研究 5 633 名女性 (平均年龄 78.5 ± 6.7) 的相对和绝对强度 PA 与主要心血管疾病 (CVD) 和全因死亡率的相关性。通过加速度计测量绝对强度。通过将加速度计估计的代谢当量 (MET) 除以最大 MET 容量来估计相对强度。两者都被汇总为光强度 PA (LPA) 和中度至强度 PA (MVPA) 的平均每日小时数。Cox 比例风险模型估计了 PA 含量高出 1 小时对结局的风险比 (HRs)。结果 随访期间 (中位 = 7.4 年),发生 748 例 CVD 事件,1 312 例死亡。无论哪种量表,较高的 LPA 和 MVPA 都与两种结局的风险降低相关。对于新发 CVD 和死亡率,绝对 LPA 增加 1 小时的 HR 分别为 0.88 (95% CI: 0.83-0.93) 和 0.88 (95% CI: 0.84-0.92)。对于相同的结局,绝对 MPVA 增加 1 小时的 HR 为 0.73 (95% CI: 0.61-0.87) 和 0.55 (95% CI: 0.48-0.64)。相对 LPA 增加 1 小时的 HR 分别为 0.70 (95% CI: 0.59-0.84) 和 0.78 (95% CI: 0.68-0.89) 对于新发 CVD 和死亡率。对于相同的结果,相对 MPVA 增加 1 小时的 HR 分别为 0.89 (95% CI: 0.83-0.96) 和 0.82 (95% CI: 0.77-0.87)。在相对量表上,LPA 比相对 MVPA 更强,并且与两种结局呈负相关。绝对 MVPA 与相对 MVPA 相比,与结局呈更强的负相关。 结论 研究结果支持 PA 强度范式继续转向建议更多运动,无论强度如何。相对 LPA——一种可改变的、更容易实现的行为目标,尤其是在非卧床老年人中——与发生重大 CVD 和死亡的风险降低相关。
更新日期:2024-05-03
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