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Risk stratification refinements with inclusion of haemodynamic variables at follow-up in patients with pulmonary arterial hypertension
European Respiratory Journal ( IF 16.6 ) Pub Date : 2024-09-05 , DOI: 10.1183/13993003.00197-2024
Athénaïs Boucly 1, 2, 3, 4 , Antoine Beurnier 1, 3, 5 , Ségolène Turquier 6 , Mitja Jevnikar 1, 2, 3 , Pascal de Groote 7 , Ari Chaouat 8 , Céline Cheron 1, 2, 3 , Xavier Jaïs 1, 2, 3 , François Picard 9 , Grégoire Prévot 10 , Anne Roche 1, 2, 3 , Sabina Solinas 1, 2, 3 , Vincent Cottin 6 , Fabrice Bauer 11 , David Montani 1, 2, 3 , Marc Humbert 1, 2, 3 , Laurent Savale 1, 2, 3, 12 , Olivier Sitbon 2, 3, 12, 13 ,
Affiliation  

Extract

Pulmonary arterial hypertension (PAH) is a cardiovascular disorder characterised by pulmonary vascular remodelling resulting in increased pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR), which can lead to progressive right heart failure [1, 2]. Right heart catheterisation (RHC) remains the gold standard for the diagnosis of pulmonary hypertension (PH) [1, 2]. Furthermore, several haemodynamic variables are included in the multiparametric model used at baseline to assess the risk of death [1, 2]. At follow-up, it is recommended to assess at least World Health Organization/New York Heart Association Functional Class (WHO/NYHA FC), 6-min walk distance (6MWD) and biomarkers (brain natriuretic peptide (BNP) or N-terminal pro-BNP (NT-proBNP)) to establish the risk status according to the non-invasive four-strata model [1, 2]. Additional variables such as haemodynamics should be considered as needed. It is left to the discretion of the physician to carry out RHC [1, 2]. However, it is not clear which patients should benefit from this examination.



中文翻译:


肺动脉高压患者随访时纳入血流动力学变量的风险分层细化


 提炼


肺动脉高压(PAH)是一种心血管疾病,其特征是肺血管重塑导致肺动脉压(PAP)和肺血管阻力(PVR)增加,可导致进行性右心衰竭[1, 2]。右心导管插入术 (RHC) 仍然是诊断肺动脉高压 (PH) 的金标准 [1, 2]。此外,基线时使用的多参数模型中包含几个血液动力学变量,用于评估死亡风险 [1, 2]。随访时,建议至少评估世界卫生组织/纽约心脏协会功能等级 (WHO/NYHA FC)、6 分钟步行距离 (6MWD) 和生物标志物(脑钠尿肽 (BNP) 或 N 末端) pro-BNP (NT-proBNP)) 根据无创四层模型建立风险状态 [1, 2]。应根据需要考虑其他变量,例如血流动力学。是否进行 RHC 由医生自行决定 [1, 2]。然而,尚不清楚哪些患者应该从这项检查中受益。

更新日期:2024-09-05
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