Small lectin ligands as a basis for applications in glycoscience and glycomedicine,Chemical Society Reviews

当前位置： X-MOL 学术 › Chem. Soc. Rev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Small lectin ligands as a basis for applications in glycoscience and glycomedicine
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2024-08-20 , DOI: 10.1039/d4cs00642a
Paul V Murphy _{1,

2,

3} , Ashis Dhara _{1,

2} , Liam S Fitzgerald _{1,

2,

3} , Eoin Hever ₁ , Saidulu Konda ₁ , Kishan Mandal ₁

Affiliation

Glycan recognition by lectins mediates important biological events. This Tutorial Review aims to introduce lectin–ligand interactions and show how these molecular recognition events inspire innovations such as: (i) glycomimetic ligands; (ii) multivalent ligand agonists/antagonists; (iii) ligands for precision delivery of therapies to cells, where therapies include vaccines, siRNA and LYTACs (iv) development of diagnostics. A small number of case studies are selected to demonstrate principles for development of new ligands for applications inspired by knowledge of natural glycan ligand structure and function.

中文翻译：

小凝集素配体作为糖科学和糖医学应用的基础

凝集素对聚糖的识别介导重要的生物事件。本教程回顾旨在介绍凝集素-配体相互作用，并展示这些分子识别事件如何激发创新，例如：（i）拟糖配体； (ii)多价配体激动剂/拮抗剂； (iii) 用于将疗法精确递送至细胞的配体，其中疗法包括疫苗、siRNA 和 LYTAC (iv) 诊断学的开发。选择少量案例研究来展示开发新配体的原理，这些配体的应用受到天然聚糖配体结构和功能知识的启发。

更新日期：2024-08-20

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南