<br>使用 NEMI、Analytical Eco-Scale、AGREE 和 GAPI 对测定油中大麻素的分析方法进行绿色度评估,Analytical Methods

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使用 NEMI、Analytical Eco-Scale、AGREE 和 GAPI 对测定油中大麻素的分析方法进行绿色度评估
Analytical Methods ( IF 2.7 ) Pub Date : 2024-08-20 , DOI: 10.1039/d4ay01083c
Nicolette Sammut Bartolo ₁ , Lovely L Gallo ₁ , Karolina Szyrner ₁ , Paul I Buhagiar ₁ , Janis Vella Szijj ₁

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大麻植物因其众多的治疗特性而受到越来越多的研究，因此需要分析技术来评估大麻植物提取物中载体油（例如中链甘油三酯（MCT）油）中存在的物质。对与分析相关的活动对环境影响的认识导致了绿色评估指标的发展。本研究旨在使用绿色分析化学指标评估用于分析石油中大麻素的分析技术对环境的影响。研究的第一阶段包括系统的文献综述，以确定分析油中大麻素的高效液相色谱和超高效液相色谱方法。在第二阶段，使用国家环境方法指数（NEMI）、分析生态尺度、分析绿色计算器（AGREE）和绿色分析程序指数（GAPI）对确定的方法进行评估。在 124 项已确定的研究中，考虑了 8 项进行比较分析。确定的分析方法包括使用高分辨率 MS ( n = 1)、DAD ( n = 2)、UV ( n = 1)、UV 和 MS ( n = 2) 以及 MS/MS ( n = 2) 作为检测器。当使用分析生态量表评估分析方法时，8 种方法中有 7 种的得分在 50 到 73 之间，将它们归类为可接受的绿色分析方法。一种方法获得了 80 分的总分，将该方法归类为优秀的绿色分析。在分析方法开发过程中应用绿色分析化学和相应指标有助于减少相关活动造成的环境足迹。

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Greenness assessment of analytical methods for determination of cannabinoids in oils using NEMI, Analytical Eco-Scale, AGREE and GAPI

The cannabis plant is being increasingly researched due to its numerous therapeutic properties leading to the need for analytical techniques to assess substances present in extracts of the cannabis plant in carrier oils, such as medium chain triglycerides (MCT) oil. Awareness of the environmental impact of activities related to analysis led to the development of greenness assessment metrics. This study aimed to assess the environmental impact of analytical techniques applied in the analysis of cannabinoids in oil using Green Analytical Chemistry metrics. The first phase of the study consisted of a systematic literature review to identify high performance liquid chromatography and ultra high performance liquid chromatographic methods of analysis for cannabinoids in oil. In the second phase, the identified methods were assessed using the National Environmental Method Index (NEMI), Analytical Eco-scale, Analytical Greenness Calculator (AGREE) and Green Analytical Procedure Index (GAPI). Out of 124 identified studies, 8 were considered for the comparative analysis. The identified analytical methods consisted of high performance liquid chromatography (HPLC) using high resolution MS (n = 1), DAD (n = 2), UV (n = 1), UV and MS (n = 2) and MS/MS (n = 2) as detectors. When the analytical methods were assessed using the Analytical Eco-Scale, 7 out of 8 methods achieved a score ranging between 50 and 73, categorising them as acceptable green methods of analysis. One method achieved a total score of 80, categorising the method as an excellent green analysis. The application of Green Analytical Chemistry and respective metrics during the development of analytical methods contributes towards a reduction in the environmental footprint which results from related activities.

更新日期：2024-08-20

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