The Hippo‐YAP/Yki pathway is critical for the regulation of physiological responses in various biological processes from invertebrates to mammals. Crustaceans, in particular shrimp and crabs, are important food sources worldwide. In response to the needs of crustacean aquaculture and disease control, the regulatory mechanisms of crustacean life activities, especially immunity, have been increasingly emphasized. Emerging clues suggest that Hippo‐Yki pathway is important for immunity and regeneration in crustaceans. In this review, the structure, activation pattern, response mechanism to pathogen invasion, and crosstalk with other signaling cascades of the Hippo‐Yki pathway in aquaculture crustaceans are summarized and its similarities and differences with those in mammals and Drosophila are investigated. Based on this, the roles of the Hippo‐Yki pathway in crustacean immune response and limb regeneration are further discussed, and the application potential of strategies pharmacologically or biologically targeting this pathway for crustacean disease control and breeding is theoretically explored.

中文翻译：

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甲壳类 Hippo-Yki 通路的最新研究进展：当前知识及其在甲壳类水产养殖中的潜在应用


Hippo-YAP/Yki 通路对于从无脊椎动物到哺乳动物的各种生物过程中的生理反应调节至关重要。甲壳类动物，特别是虾和蟹，是全世界重要的食物来源。针对甲壳类养殖和病害防治的需要，甲壳类生命活动尤其是免疫的调控机制日益受到重视。新出现的线索表明 Hippo-Yki 通路对于甲壳类动物的免疫和再生很重要。本文综述了水产甲壳类Hippo-Yki通路的结构、激活模式、对病原体入侵的响应机制以及与其他信号级联的串扰，并总结了其与哺乳动物和哺乳动物中Hippo-Yki通路的异同。果蝇被调查。在此基础上，进一步探讨了Hippo-Yki通路在甲壳动物免疫反应和肢体再生中的作用，并从理论上探讨了针对该通路的药理学或生物学策略在甲壳动物疾病控制和育种中的应用潜力。