A safety guide for transgenic Cre drivers in metabolism,Nature Metabolism

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A safety guide for transgenic Cre drivers in metabolism
Nature Metabolism ( IF 18.9 ) Pub Date : 2024-08-19 , DOI: 10.1038/s42255-024-01087-8
Carla Horvath ₁ , Christian Wolfrum ₁ , Pawel Pelczar ₂

Affiliation

Despite the high utility and widespread use of Cre driver lines, lack of Cre specificity, Cre-induced toxicity or poor experimental design can affect experimental results and conclusions. Such pitfalls must be considered before embarking on any Cre-based studies in metabolic research.

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