The HOPE cohort is a Danish nationwide cohort with ongoing follow-up, holding information on postpartum depression (PPD) symptoms and diagnoses on 170,218 childbirths (142,795 unique mothers). These data have been linked with extensive register data on health and socioeconomic information on the mothers, their partners, parents, and children. This cohort profile aimed to provide an overview of the data collection and content, describe characteristics, and evaluate potential selection bias. PPD screenings, using the Edinburgh Postnatal Depression Scale, were collected from 67 of the 98 Danish municipalities, covering the period January 2015 to December 2021. This data was linked with register data on PPD diagnoses (identified through medication prescriptions and hospital contacts) as well as background information. Cohort characteristics were compared to the source population, defined as all childbirths by women residing in Denmark during the same period (452,207 childbirths). Potential selection bias was evaluated by comparing odds ratios of five well-established associations between the cohort and the source population. The HOPE cohort holds information on 170,218 childbirths (38% of the source population) involving 142,795 unique mothers. The HOPE cohort only differed slightly from the source population on most characteristics examined, but larger differences were observed on specific characteristics with an underrepresentation of the youngest and oldest age groups, women with more than three children or twins/triplets, and women born outside Denmark. Similar associations were identified across the two populations within the five well-established associations. There was no indication of selection bias on the five examined associations, and the HOPE cohort is representative of the source population on important perinatal characteristics.

HOPE 队列是丹麦全国范围内的队列，正在进行随访，拥有 170,218 名分娩者（142,795 名不同母亲）的产后抑郁症 (PPD) 症状和诊断信息。这些数据已与母亲、其伴侣、父母和儿童的健康和社会经济信息的广泛登记数据相关联。该队列概况旨在提供数据收集和内容的概述、描述特征并评估潜在的选择偏差。使用爱丁堡产后抑郁量表从丹麦 98 个城市中的 67 个城市收集了 2015 年 1 月至 2021 年 12 月期间的 PPD 筛查。该数据还与 PPD 诊断的登记数据（通过药物处方和医院联系方式确定）相关联。作为背景信息。将队列特征与源人口进行比较，源人口定义为同一时期居住在丹麦的妇女的所有分娩（452,207 次分娩）。通过比较队列和源人群之间五个已确立的关联的比值比来评估潜在的选择偏倚。 HOPE 队列拥有 170,218 次分娩的信息（占源人口的 38%），涉及 142,795 名不同的母亲。 HOPE 队列在大多数检查特征上与源人群仅略有不同，但在特定特征上观察到较大差异，其中最年轻和最年长年龄组、有三个以上孩子或双胞胎/三胞胎的妇女以及在丹麦境外出生的妇女的代表性不足。在五个成熟关联中的两个人群中发现了类似的关联。 所检查的五个关联中没有任何选择偏倚的迹象，并且 HOPE 队列在重要的围产期特征方面代表了源人群。