Recent advancements in atherosclerosis management have shifted focus beyond lipid-lowering strategies towards addressing residual inflammatory risks associated with major adverse cardiovascular events. In a recent Cell Research paper, Fan et al. reported that anti-PD-1 monoclonal antibody therapy reduces atherosclerosis plaque size and modulates inflammation by serving as a surrogate PD-1 ligand through interaction with myeloid-expressed Fc gamma receptors.

中文翻译：

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通过靶向促炎性 T 细胞治疗动脉粥样硬化

动脉粥样硬化治疗的最新进展已将焦点从降脂策略转向解决与主要不良心血管事件相关的残留炎症风险。在最近的一篇细胞研究论文中，Fan 等人。报道称，抗 PD-1 单克隆抗体疗法通过与骨髓表达的 Fc γ 受体相互作用，作为替代 PD-1 配体，减少动脉粥样硬化斑块大小并调节炎症。