Glycosaminoglycans (GAGs) are extensively utilized in clinical, cosmetic, and healthcare field, as well as in the treatment of thrombosis, osteoarthritis, rheumatism, and cancer. The biological production of GAGs is a strategy that has garnered significant attention due to its numerous advantages over traditional preparation methods. In this review, we embark on a journey to decode the intricate molecular symphony that orchestrates the biosynthesis of glycosaminoglycans. By unraveling the complex interplay of related enzymes and thorough excavation of the intricate metabolic cascades involved, GAGs chain aggregation and transportation, which efficiently and controllably modulate GAGs sulfation patterns involved in biosynthetic pathway, we endeavor to offer a thorough comprehension of how these remarkable GAGs are intricately assembled and pushes the boundaries of our understanding in GAGs biosynthesis.

中文翻译：

---

揭开糖胺聚糖生物合成的复杂性：解码理解复杂多糖组装的分子交响乐


糖胺聚糖（GAG）广泛应用于临床、美容和保健领域，以及治疗血栓、骨关节炎、风湿病和癌症。 GAG 的生物生产是一种由于其相对于传统制备方法具有众多优势而引起广泛关注的策略。在这篇综述中，我们踏上了解码编排糖胺聚糖生物合成的复杂分子交响曲的旅程。通过揭示相关酶之间复杂的相互作用，并深入挖掘所涉及的复杂代谢级联、GAGs链聚集和运输，有效且可控地调节生物合成途径中涉及的GAGs硫酸化模式，我们努力全面理解这些非凡的GAGs是如何发挥作用的。错综复杂的组装并突破了我们对 GAG 生物合成的理解界限。