As our comprehension of the intricate relationship between cellular senescence and tumor biology continues to evolve, the therapeutic potential of cellular senescence is gaining increasing recognition. Here, we identify chromobox 4 (CBX4), a Small Ubiquitin-related Modifier (SUMO) E3 ligase, as an antagonist of cellular senescence and elucidate a novel mechanism by which CBX4 promotes drug resistance and malignant progression of gastric cancer (GC).

中文翻译：

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CBX4 通过诱导 YAP1 SUMOylation 来抵消细胞衰老，使胃癌细胞对化疗脱敏


随着我们对细胞衰老与肿瘤生物学之间复杂关系的理解不断发展，细胞衰老的治疗潜力越来越得到认可。在这里，我们将小泛素相关修饰剂 （SUMO） E3 连接酶 chromobox 4 （CBX4） 确定为细胞衰老的拮抗剂，并阐明了 CBX4 促进胃癌耐药和恶性进展的新机制 （GC）。